\n
\n\tBulgular\u0131n, ara\u015ft\u0131rmac\u0131lar\u0131n lokal anesteziyi insanlarda daha uzun s\u00fcre etkili hale getirmesine yard\u0131mc\u0131 olabilece\u011fi belirtildi.<\/p>\n
\n\tAmeliyattan sonra iyile\u015fme s\u00fcrecindeki hastalar\u0131n, \u00e7o\u011fu lokal anestezi y\u00f6nteminin sa\u011flad\u0131\u011f\u0131 sekiz ila on iki saatlik veya en fazla bir g\u00fcnl\u00fck s\u00fcrenin \u00f6tesinde a\u011fr\u0131 kesiciye ihtiya\u00e7 duyabildi\u011fi biliniyor.<\/p>\n
\n\tDaha uzun s\u00fcreli bir se\u00e7enek arayan Boston \u00c7ocuk Hastanesindeki ara\u015ft\u0131rmac\u0131lar, ya\u011fl\u0131 molek\u00fcllerden olu\u015fan mikroskobik ta\u015f\u0131y\u0131c\u0131lar olan lipozomlar\u0131, ilac\u0131 daha yava\u015f salacak \u015fekilde yeniden tasarlad\u0131.<\/p>\n
\n\tTicari bir form\u00fclasyonun yakla\u015f\u0131k d\u00f6rt ila sekiz saatlik etkisine k\u0131yasla, yeni form\u00fclasyonun farelerde lokal anesteziyi iki ila \u00fc\u00e7 hafta boyunca s\u00fcrd\u00fcrd\u00fc\u011f\u00fc kaydedildi.<\/p>\n
\n\t\u0130la\u00e7lar\u0131n lipozomlardan nas\u0131l s\u0131zd\u0131\u011f\u0131 yeniden de\u011ferlendirildi<\/h2>\n
\n\tOn y\u0131llard\u0131r doktorlar ila\u00e7lar\u0131 kademeli olarak salmak i\u00e7in lipozomlar\u0131 kullan\u0131rken, ilac\u0131n lipozomlardan ne kadar s\u00fcrede s\u0131zd\u0131\u011f\u0131n\u0131 lipit ad\u0131 verilen ya\u011fl\u0131 bile\u015fenler belirliyor.<\/p>\n
\n\tBilim insanlar\u0131 genel olarak gev\u015fek paketlenmi\u015f, daha ak\u0131\u015fkan lipitlerin ila\u00e7lar\u0131n daha h\u0131zl\u0131 s\u0131zmas\u0131na izin vermesini bekliyordu. Bu h\u0131zl\u0131 sal\u0131n\u0131m\u0131n daha g\u00fc\u00e7l\u00fc ancak daha k\u0131sa s\u00fcreli bir etki yaratabildi\u011fi ve toksisite riskini art\u0131rabildi\u011fi biliniyor.<\/p>\n
\n\tDoktor Daniel Kohane’nin laboratuvar\u0131nda \u00e7al\u0131\u015fan ara\u015ft\u0131rma m\u00fchendisi Doktor Yuan Wang, suda \u00e7\u00f6z\u00fcnen ila\u00e7lar\u0131n farkl\u0131 davrand\u0131\u011f\u0131n\u0131 tespit etti. Suyla kolayca kar\u0131\u015ft\u0131klar\u0131 veya suda \u00e7\u00f6z\u00fcnd\u00fckleri i\u00e7in hidrofilik ila\u00e7lar olarak bilinen bu ila\u00e7lar\u0131n, daha ak\u0131\u015fkan lipozomlardan son derece yava\u015f s\u0131zd\u0131\u011f\u0131 anla\u015f\u0131ld\u0131.<\/p>\n
\n\tKirpi bal\u0131\u011f\u0131 zehrinin a\u011fr\u0131 kesici potansiyeli<\/h2>\n
\n\tAra\u015ft\u0131rmac\u0131lar bu daha yava\u015f sal\u0131n\u0131m\u0131n bir sinir blo\u011funu s\u00fcrd\u00fcr\u00fcp s\u00fcrd\u00fcremeyece\u011fini test etmek i\u00e7in ta\u015f\u0131y\u0131c\u0131lar\u0131, kirpi bal\u0131\u011f\u0131 ve mavi halkal\u0131 ahtapotlarda bulunan ve ayn\u0131 zamanda g\u00fc\u00e7l\u00fc bir uyu\u015fturucu madde olarak da i\u015flev g\u00f6ren tetrodotoksin ile doldurdu.<\/p>\n
\n\tForm\u00fclasyonu farelerin bacaklar\u0131ndaki bir sinirin yak\u0131n\u0131na enjekte eden ekip, enjeksiyon b\u00f6lgesinde veya v\u00fccudun ba\u015fka bir yerinde toksisiteye rastlamad\u0131. Sonu\u00e7lar, ilac\u0131n b\u00f6lgeyi uyu\u015fturmaya yetecek seviyeleri korurken v\u00fccudun onu temizleyebilece\u011fi kadar yava\u015f sal\u0131nd\u0131\u011f\u0131n\u0131 g\u00f6sterdi.<\/p>\n
\n\tNature Biomedical Engineering dergisinde yay\u0131mlanan \u00e7al\u0131\u015fmaya g\u00f6re, sinir bloklar\u0131 insanlarda farelere k\u0131yasla genellikle daha uzun s\u00fcrse de tetrodotoksinin hen\u00fcz hastalarda ticari olarak kullan\u0131lmad\u0131\u011f\u0131 biliniyor.<\/p>\n
\n\tBoston \u00c7ocuk Hastanesinde pediatrik yo\u011fun bak\u0131m uzman\u0131 ve Biyomateryaller ile \u0130la\u00e7 \u0130letimi Laboratuvar\u0131 Direkt\u00f6r\u00fc olan Kohane, ameliyat d\u00f6nemi a\u011fr\u0131lar\u0131 i\u00e7in olas\u0131 uygulamalar\u0131 de\u011ferlendiriyor.<\/p>\n
\n\tKohane, bu uzat\u0131lm\u0131\u015f sal\u0131n\u0131ml\u0131 kombinasyonun opioidler yerine uzun s\u00fcreli ameliyat d\u00f6nemi a\u011fr\u0131lar\u0131 i\u00e7in kullan\u0131labilece\u011fini ve bunu kronik a\u011fr\u0131lar i\u00e7in de de\u011ferlendirmeye ba\u015flad\u0131klar\u0131n\u0131 s\u00f6yledi. Kohane ayr\u0131ca bu lipozomlar\u0131n \u00e7ok \u00e7e\u015fitli hidrofilik molek\u00fcllerin yava\u015f sal\u0131n\u0131m\u0131n\u0131 da sa\u011flayabildi\u011fini kaydetti.<\/p>\n
\n\t\u0130la\u00e7 sal\u0131n\u0131m\u0131n\u0131 yava\u015flatan lipozomlar\u0131n i\u00e7 yap\u0131s\u0131<\/h2>\n
\n\tYava\u015f sal\u0131n\u0131m\u0131n nedeni, lipitlerin ta\u015f\u0131y\u0131c\u0131lar halinde nas\u0131l birle\u015fti\u011fini inceleyen deneylerden ortaya \u00e7\u0131kt\u0131. Lipitlerin kuyruklar\u0131na \u00e7ok say\u0131da \u00e7ift kimyasal ba\u011f eklemek, molek\u00fcllerin birbirine s\u0131k\u0131ca paketlenmesini \u00f6nleyerek zarlar\u0131 daha ak\u0131\u015fkan hale getiriyor.<\/p>\n
\n\tAra\u015ft\u0131rmac\u0131lar, \u00e7ok say\u0131da \u00e7ift ba\u011f ile yap\u0131lan lipozomlar\u0131n birden fazla b\u00f6lme i\u00e7erdi\u011fini, \u00e7ift ba\u011f olmayanlar\u0131n ise basit k\u00fcresel bir yap\u0131ya sahip oldu\u011funu buldu.<\/p>\n
\n\tDaha fazla \u00e7ift ba\u011fa sahip lipozomlardaki daha ak\u0131\u015fkan zarlar\u0131 ge\u00e7menin daha kolay olabilece\u011fini belirten Wang, daha fazla say\u0131daki bariyerin ilac\u0131n sal\u0131n\u0131m\u0131n\u0131 yava\u015flatt\u0131\u011f\u0131n\u0131 ifade etti. Wang, daha fazla \u00e7ift ba\u011fa sahip ak\u0131\u015fkan lipozomlar\u0131n, \u00e7ok katmanl\u0131 so\u011fanlar gibi e\u015f merkezli k\u00fcreler, hatta potansiyel olarak k\u00fcreler i\u00e7inde k\u00fcreler olu\u015fturabildi\u011fini s\u00f6yledi.<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"
Bulgular\u0131n, ara\u015ft\u0131rmac\u0131lar\u0131n lokal anesteziyi insanlarda daha uzun s\u00fcre etkili hale getirmesine yard\u0131mc\u0131 olabilece\u011fi belirtildi.
Ameliyattan sonra iyile\u015fme s\u00fcrecindeki hastalar\u0131n, \u00e7o\u011fu lokal anestezi y\u00f6nteminin sa\u011flad\u0131\u011f\u0131 sekiz ila on iki saatlik veya en fazla bir g\u00fcnl\u00fck s\u00fcrenin \u00f6tesinde a\u011fr\u0131 kesiciye ihtiya\u00e7 duyabildi\u011fi biliniyor.
Daha uzun s\u00fcreli bir se\u00e7enek arayan Boston \u00c7ocuk Hastanesindeki ara\u015ft\u0131rmac\u0131lar, ya\u011fl\u0131 […]<\/p>\n","protected":false},"author":1,"featured_media":49967,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jnews-multi-image_gallery":[],"jnews_single_post":[],"jnews_primary_category":[],"jnews_social_meta":[],"jnews_override_counter":[],"footnotes":""},"categories":[2],"tags":[],"class_list":["post-49966","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dunya"],"yoast_head":"\n
Bilim insanlar\u0131 saatler yerine haftalarca etkili lokal anestezi geli\u015ftirdi - Haber Ver K\u0131br\u0131s<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/haberverkibris.com\/index.php\/2026\/10\/03\/bilim-insanlari-saatler-yerine-haftalarca-etkili-lokal-anestezi-gelistirdi\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bilim insanlar\u0131 saatler yerine haftalarca etkili lokal anestezi geli\u015ftirdi - Haber Ver K\u0131br\u0131s\" \/>\n<meta property=\"og:description\" content=\"
Bulgular\u0131n, ara\u015ft\u0131rmac\u0131lar\u0131n lokal anesteziyi insanlarda daha uzun s\u00fcre etkili hale getirmesine yard\u0131mc\u0131 olabilece\u011fi belirtildi.
Ameliyattan sonra iyile\u015fme s\u00fcrecindeki hastalar\u0131n, \u00e7o\u011fu lokal anestezi y\u00f6nteminin sa\u011flad\u0131\u011f\u0131 sekiz ila on iki saatlik veya en fazla bir g\u00fcnl\u00fck s\u00fcrenin \u00f6tesinde a\u011fr\u0131 kesiciye ihtiya\u00e7 duyabildi\u011fi biliniyor.
Daha uzun s\u00fcreli bir se\u00e7enek arayan Boston \u00c7ocuk Hastanesindeki ara\u015ft\u0131rmac\u0131lar, ya\u011fl\u0131 […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/haberverkibris.com\/index.php\/2026\/10\/03\/bilim-insanlari-saatler-yerine-haftalarca-etkili-lokal-anestezi-gelistirdi\/\" \/>\n<meta property=\"og:site_name\" content=\"Haber Ver K\u0131br\u0131s\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/kuzeyinsesii\" \/>\n<meta property=\"article:published_time\" content=\"2026-10-03T04:30:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/trthaberstatic.cdn.wp.trt.com.tr\/resimler\/2136000\/kok-hucre-2137144.jpg\" \/>\n<meta name=\"author\" content=\"Haberver K\u0131br\u0131s\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@kuzeyinsesii\" \/>\n<meta name=\"twitter:site\" content=\"@kuzeyinsesii\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"Haberver K\u0131br\u0131s\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/haberverkibris.com\\\/index.php\\\/2026\\\/10\\\/03\\\/bilim-insanlari-saatler-yerine-haftalarca-etkili-lokal-anestezi-gelistirdi\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/haberverkibris.com\\\/index.php\\\/2026\\\/10\\\/03\\\/bilim-insanlari-saatler-yerine-haftalarca-etkili-lokal-anestezi-gelistirdi\\\/\"},\"author\":{\"name\":\"Haberver K\u0131br\u0131s\",\"@id\":\"https:\\\/\\\/haberverkibris.com\\\/#\\\/schema\\\/person\\\/29d65381ed43765483b5a185ded66a56\"},\"headline\":\"Bilim insanlar\u0131 saatler yerine haftalarca etkili lokal anestezi geli\u015ftirdi\",\"datePublished\":\"2026-10-03T04:30:07+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/haberverkibris.com\\\/index.php\\\/2026\\\/10\\\/03\\\/bilim-insanlari-saatler-yerine-haftalarca-etkili-lokal-anestezi-gelistirdi\\\/\"},\"wordCount\":684,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/haberverkibris.com\\\/index.php\\\/2026\\\/10\\\/03\\\/bilim-insanlari-saatler-yerine-haftalarca-etkili-lokal-anestezi-gelistirdi\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/haberverkibris.com\\\/wp-content\\\/uploads\\\/2026\\\/10\\\/kok-hucre-2137144.jpg\",\"articleSection\":[\"D\u00fcnya\"],\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/haberverkibris.com\\\/index.php\\\/2026\\\/10\\\/03\\\/bilim-insanlari-saatler-yerine-haftalarca-etkili-lokal-anestezi-gelistirdi\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/haberverkibris.com\\\/index.php\\\/2026\\\/10\\\/03\\\/bilim-insanlari-saatler-yerine-haftalarca-etkili-lokal-anestezi-gelistirdi\\\/\",\"url\":\"https:\\\/\\\/haberverkibris.com\\\/index.php\\\/2026\\\/10\\\/03\\\/bilim-insanlari-saatler-yerine-haftalarca-etkili-lokal-anestezi-gelistirdi\\\/\",\"name\":\"Bilim insanlar\u0131 saatler yerine haftalarca etkili lokal anestezi geli\u015ftirdi - 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Haber Ver K\u0131br\u0131s","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/haberverkibris.com\/index.php\/2026\/10\/03\/bilim-insanlari-saatler-yerine-haftalarca-etkili-lokal-anestezi-gelistirdi\/","og_locale":"tr_TR","og_type":"article","og_title":"Bilim insanlar\u0131 saatler yerine haftalarca etkili lokal anestezi geli\u015ftirdi - Haber Ver K\u0131br\u0131s","og_description":"
Bulgular\u0131n, ara\u015ft\u0131rmac\u0131lar\u0131n lokal anesteziyi insanlarda daha uzun s\u00fcre etkili hale getirmesine yard\u0131mc\u0131 olabilece\u011fi belirtildi.
Ameliyattan sonra iyile\u015fme s\u00fcrecindeki hastalar\u0131n, \u00e7o\u011fu lokal anestezi y\u00f6nteminin sa\u011flad\u0131\u011f\u0131 sekiz ila on iki saatlik veya en fazla bir g\u00fcnl\u00fck s\u00fcrenin \u00f6tesinde a\u011fr\u0131 kesiciye ihtiya\u00e7 duyabildi\u011fi biliniyor.
Daha uzun s\u00fcreli bir se\u00e7enek arayan Boston \u00c7ocuk Hastanesindeki ara\u015ft\u0131rmac\u0131lar, ya\u011fl\u0131 […]","og_url":"https:\/\/haberverkibris.com\/index.php\/2026\/10\/03\/bilim-insanlari-saatler-yerine-haftalarca-etkili-lokal-anestezi-gelistirdi\/","og_site_name":"Haber Ver K\u0131br\u0131s","article_publisher":"https:\/\/www.facebook.com\/kuzeyinsesii","article_published_time":"2026-10-03T04:30:07+00:00","og_image":[{"url":"https:\/\/trthaberstatic.cdn.wp.trt.com.tr\/resimler\/2136000\/kok-hucre-2137144.jpg","type":"","width":"","height":""}],"author":"Haberver K\u0131br\u0131s","twitter_card":"summary_large_image","twitter_creator":"@kuzeyinsesii","twitter_site":"@kuzeyinsesii","twitter_misc":{"Yazan:":"Haberver K\u0131br\u0131s","Tahmini okuma s\u00fcresi":"3 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/haberverkibris.com\/index.php\/2026\/10\/03\/bilim-insanlari-saatler-yerine-haftalarca-etkili-lokal-anestezi-gelistirdi\/#article","isPartOf":{"@id":"https:\/\/haberverkibris.com\/index.php\/2026\/10\/03\/bilim-insanlari-saatler-yerine-haftalarca-etkili-lokal-anestezi-gelistirdi\/"},"author":{"name":"Haberver K\u0131br\u0131s","@id":"https:\/\/haberverkibris.com\/#\/schema\/person\/29d65381ed43765483b5a185ded66a56"},"headline":"Bilim insanlar\u0131 saatler yerine haftalarca etkili lokal anestezi geli\u015ftirdi","datePublished":"2026-10-03T04:30:07+00:00","mainEntityOfPage":{"@id":"https:\/\/haberverkibris.com\/index.php\/2026\/10\/03\/bilim-insanlari-saatler-yerine-haftalarca-etkili-lokal-anestezi-gelistirdi\/"},"wordCount":684,"commentCount":0,"image":{"@id":"https:\/\/haberverkibris.com\/index.php\/2026\/10\/03\/bilim-insanlari-saatler-yerine-haftalarca-etkili-lokal-anestezi-gelistirdi\/#primaryimage"},"thumbnailUrl":"https:\/\/haberverkibris.com\/wp-content\/uploads\/2026\/10\/kok-hucre-2137144.jpg","articleSection":["D\u00fcnya"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/haberverkibris.com\/index.php\/2026\/10\/03\/bilim-insanlari-saatler-yerine-haftalarca-etkili-lokal-anestezi-gelistirdi\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/haberverkibris.com\/index.php\/2026\/10\/03\/bilim-insanlari-saatler-yerine-haftalarca-etkili-lokal-anestezi-gelistirdi\/","url":"https:\/\/haberverkibris.com\/index.php\/2026\/10\/03\/bilim-insanlari-saatler-yerine-haftalarca-etkili-lokal-anestezi-gelistirdi\/","name":"Bilim insanlar\u0131 saatler yerine haftalarca etkili lokal anestezi geli\u015ftirdi - 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